Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients.
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ABSTRACT:
SUBMITTER: Paez-Franco JC
PROVIDER: S-EPMC7973513 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
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Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients.
Páez-Franco José C JC Torres-Ruiz Jiram J Sosa-Hernández Víctor A VA Cervantes-Díaz Rodrigo R Romero-Ramírez Sandra S Pérez-Fragoso Alfredo A Meza-Sánchez David E DE Germán-Acacio Juan Manuel JM Maravillas-Montero José L JL Mejía-Domínguez Nancy R NR Ponce-de-León Alfredo A Ulloa-Aguirre Alfredo A Gómez-Martín Diana D Llorente Luis L
Scientific reports 20210318 1
We identified the main changes in serum metabolites associated with severe (n = 46) and mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy, three α-hydroxyl acids of amino acid origin increased with disease severity and correlated with altered oxygen saturation levels and clinical markers of lung damage. We hypothesize that the enzymatic conversio ...[more]
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