Birthweight DNA methylation signatures in infant saliva.

ABSTRACT:

Background

Low birthweight has been repeatedly associated with long-term adverse health outcomes and many non-communicable diseases. Our aim was to look-up cord blood birthweight-associated CpG sites identified by the PACE Consortium in infant saliva, and to explore saliva-specific DNA methylation signatures of birthweight.

Methods

DNA methylation was assessed using Infinium HumanMethylation450K array in 135 saliva samples collected from children of the NINFEA birth cohort at an average age of 10.8 (range 7-17) months. The association analyses between birthweight and DNA methylation variations were carried out using robust linear regression models both in the exploratory EWAS analyses and in the look-up of the PACE findings in infant saliva.

Results

None of the cord b

SUBMITTER: Moccia C 

PROVIDER: S-EPMC7980592 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature