Effect of single- versus double-layer uterine closure during caesarean section on postmenstrual spotting (2Close): multicentre, double-blind, randomised controlled superiority trial.

ABSTRACT:

Objective

To evaluate whether double-layer uterine closure after a first caesarean section (CS) is superior compared with single-layer uterine closure in terms of postmenstrual spotting and niche development in the uterine caesarean scar.

Design

Multicentre, double-blind, randomised controlled superiority trial.

Setting

Thirty-two hospitals in the Netherlands.

Population

A total of 2292 women aged ≥18 years undergoing a first CS were randomly assigned to each procedure (1:1): 1144 women were assigned to single-layer uterine closure and 1148 women were assigned to double-layer uterine closure.

Methods

Single-layer unlocked closure and double-layer unlocked closure, with the second layer imbricating the first.

Main outcome measures

Number of days wi

SUBMITTER: Stegwee SI 

PROVIDER: S-EPMC7983985 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature