Accelerated J-resolved ¹ H-MRSI with limited and sparse sampling of ( k,t1,t2 -space.

ABSTRACT:

Purpose

To accelerate the acquisition of J-resolved proton magnetic resonance spectroscopic imaging (¹ H-MRSI) data for high-resolution mapping of brain metabolites and neurotransmitters.

Methods

The proposed method used a subspace model to represent multidimensional spatiospectral functions, which significantly reduced the number of parameters to be determined from J-resolved ¹ H-MRSI data. A semi-LASER-based (Localization by Adiabatic SElective Refocusing) echo-planar spectroscopic imaging (EPSI) sequence was used for data acquisition. The proposed data acquisition scheme sampled k,t1,t2 -space in variable density, where t₁ and t₂ specify the J-coupling and chemical-shift encoding times, respectively. Selection of the J-coupling

SUBMITTER: Tang L 

PROVIDER: S-EPMC7992196 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature