Citron Essential Oils Alleviate the Mediators Related to Rosacea Pathophysiology in Epidermal Keratinocytes.

ABSTRACT:

Background

Citron is well known for an abundance of antioxidative and anti-inflammatory ingredients such as vitamin C, polyphenol compounds, flavonoids, and limonoids.

Objective

In this study, we aimed to evaluate the effects of citron essential oils on rosacea mediators in activated keratinocytes in vitro.

Methods

Normal human epidermal keratinocytes (NHEKs) were stimulated with 1α, 25-dihydroxyvitamin D₃ (VD₃) and interleukin 33 (IL-33) with LL-37 to induce rosacea mediators such as kallikrein 5 (KLK5), cathelicidin, vascular endothelial growth factor (VEGF), and transient receptor potential vanilloid 1 (TRPV1). These mediators were analyzed by performing reverse-transcription polymerase chain reaction (PCR), quantitative real-time PCR,

SUBMITTER: Jeon HW 

PROVIDER: S-EPMC7992447 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature