Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function.

ABSTRACT:

Objectives

The intestinal microbiome can modulate immune function through production of microbial-derived short-chain fatty acids. We explored whether intestinal dysbiosis in children with sepsis leads to changes in microbial-derived short-chain fatty acids in plasma and stool that are associated with immunometabolic dysfunction in peripheral blood mononuclear cells.

Design

Prospective observational pilot study.

Setting

Single academic PICU.

Patients

Forty-three children with sepsis/septic shock and 44 healthy controls.

Measurements and main results

Stool and plasma samples were serially collected for sepsis patients; stool was collected once for controls. The intestinal microbiome was assessed using 16S ribosomal RNA sequencing and alpha- and beta-diver

SUBMITTER: Weiss SL 

PROVIDER: S-EPMC7994045 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature