A KDM5-Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation.

ABSTRACT: Mutations in the lysine demethylase 5 (KDM5) family of transcriptional regulators are associated with intellectual disability, yet little is known regarding their spatiotemporal requirements or neurodevelopmental contributions. Utilizing the mushroom body (MB), a major learning and memory center within the Drosophila brain, we demonstrate that KDM5 is required within ganglion mother cells and immature neurons for proper axogenesis. Moreover, the mechanism by which KDM5 functions in this context is independent of its canonical histone demethylase activity. Using in vivo transcriptional and binding analyses, we identify a network of genes directly regulated by KDM5 that are critical modulators of neurodevelopment. We find that KDM5 directly regulates the expression of prospero,

SUBMITTER: Hatch HAM 

PROVIDER: S-EPMC7997662 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature