The Functional Vision Protection Effect of Danshensu via Dopamine D1 Receptors: In Vivo Study.

ABSTRACT: Danshensu, a traditional herb-based active component (Salvia miltiorrhiza Bunge), has garnered attention, due to its safety, nutritional value, and antioxidant effects, along with cardiovascular-protective and neuroprotective abilities; however, its effect on the retinal tissues and functional vision has not been fully studied. The objective of this study was to analyze the protective effect of danshensu on retinal tissues and functional vision in vivo in a mouse model of light-induced retinal degeneration. High energy light-evoked visual damage was confirmed by the loss in structural tissue integrity in the retina accompanied by a decline in visual acuity and visual contrast sensitivity function (VCSF), whereas the retina tissue exhibited severe Müller cell gliosis. Although danshe

SUBMITTER: Chen YW 

PROVIDER: S-EPMC8002943 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature