Establishment of inflammatory model induced by Pseudorabies virus infection in mice.

ABSTRACT:

Background

Pseudorabies virus (PRV) infection leads to high mortality in swine. Despite extensive efforts, effective treatments against PRV infection are limited. Furthermore, the inflammatory response induced by PRV strain GXLB-2013 is unclear.

Objectives

Our study aimed to investigate the inflammatory response induced by PRV strain GXLB-2013, establish an inflammation model to elucidate the pathogenesis of PRV infection further, and develop effective drugs against PRV infection.

Methods

Kunming mice were infected intramuscularly with medium, LPS, and different doses of PRV-GXLB-2013. Viral spread and histopathological damage to brain, spleen, and lung were determined at 7 days post-infection (dpi). Immune organ indices, levels of reactive oxygen species (ROS)

SUBMITTER: Ren CZ 

PROVIDER: S-EPMC8007442 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature