Alternative splicing of OAS1 alters the risk for severe COVID-19.

ABSTRACT: A locus containing OAS1/2/3 has been identified as a risk locus for severe COVID-19 among Europeans ancestry individuals, with a protective haplotype of ∼75 kilobases derived from Neanderthals. Here, we show that among several potentially causal variants at this locus, a splice variant of OAS1 occurs in people of African ancestry independently of the Neanderthal haplotype and confers protection against COVID-19 of a magnitude similar to that seen in individuals without African ancestry.

SUBMITTER: Huffman J 

PROVIDER: S-EPMC8010745 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature