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Alternative splicing of OAS1 alters the risk for severe COVID-19.

ABSTRACT: A locus containing OAS1/2/3 has been identified as a risk locus for severe COVID-19 among Europeans ancestry individuals, with a protective haplotype of ∼75 kilobases derived from Neanderthals. Here, we show that among several potentially causal variants at this locus, a splice variant of OAS1 occurs in people of African ancestry independently of the Neanderthal haplotype and confers protection against COVID-19 of a magnitude similar to that seen in individuals without African ancestry.

SUBMITTER: Huffman J

PROVIDER: S-EPMC8010745 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Alternative splicing of OAS1 alters the risk for severe COVID-19.

Huffman Jennifer J Butler-Laporte Guillaume G Khan Atlas A Drivas Theodore G TG Peloso Gina M GM Nakanishi Tomoko T Verma Anurag A Kiryluk Krzysztof K Richards J Brent JB Zeberg Hugo H

medRxiv : the preprint server for health sciences 20210325

A locus containing OAS1/2/3 has been identified as a risk locus for severe COVID-19 among Europeans ancestry individuals, with a protective haplotype of ∼75 kilobases derived from Neanderthals. Here, we show that among several potentially causal variants at this locus, a splice variant of OAS1 occurs in people of African ancestry independently of the Neanderthal haplotype and confers protection against COVID-19 of a magnitude similar to that seen in individuals without African ance ...[more]

PMID: 33791713

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