Phenotypic profiling of mGlu₇ knockout mice reveals new implications for neurodevelopmental disorders.

ABSTRACT: Neurodevelopmental disorders are characterized by deficits in communication, cognition, attention, social behavior and/or motor control. Previous studies have pointed to the involvement of genes that regulate synaptic structure and function in the pathogenesis of these disorders. One such gene, GRM7, encodes the metabotropic glutamate receptor 7 (mGlu₇ ), a G protein-coupled receptor that regulates presynaptic neurotransmitter release. Mutations and polymorphisms in GRM7 have been associated with neurodevelopmental disorders in clinical populations; however, limited preclinical studies have evaluated mGlu₇ in the context of this specific disease class. Here, we show that the absence of mGlu₇ in mice is sufficient to alter phenotypes within the domains of so

SUBMITTER: Fisher NM 

PROVIDER: S-EPMC8034495 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature