Improvement of pathological staging system for neuroendocrine tumors of the lung.

ABSTRACT:

Background

Currently, the tumor, node, and metastasis (TNM) staging system has a limited value in prognostic stratification for neuroendocrine tumors of the lung (NETL). A specific pathological staging system was therefore explored.

Methods

Two cohorts were assessed: the training cohort was composed of surgically treated patients from the Surveillance, Epidemiologic, and End Results (SEER) database [2004-2015]; the Shanghai cohort included Shanghai resident patients treated at Shanghai Pulmonary Hospital [2009-2018]. Multivariable Cox regression analysis was performed to identify factors associated with overall survival. A new staging system was proposed based on survival tree, and was further compared with the 8^th edition of the TNM staging system.

Results

SUBMITTER: Yi C 

PROVIDER: S-EPMC8039668 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature