Quantitative methods for metabolomic analyses evaluated in the Children's Health Exposure Analysis Resource (CHEAR).
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ABSTRACT:
SUBMITTER: CHEAR Metabolomics Analysis Team
PROVIDER: S-EPMC8041023 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
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Quantitative methods for metabolomic analyses evaluated in the Children's Health Exposure Analysis Resource (CHEAR).
Mazzella Matthew M Sumner Susan J SJ Gao Shangzhi S Su Li L Diao Nancy N Mostofa Golam G Qamruzzaman Qazi Q Pathmasiri Wimal W Christiani David C DC Fennell Timothy T Gennings Chris C
Journal of exposure science & environmental epidemiology 20190923 1
With advances in technologies that facilitate metabolome-wide analyses, the incorporation of metabolomics in the pursuit of biomarkers of exposure and effect is rapidly evolving in population health studies. However, many analytic approaches are limited in their capacity to address high-dimensional metabolomics data within an epidemiologic framework, including the highly collinear nature of the metabolites and consideration of confounding variables. In this Children's Health Exposure Analysis Re ...[more]
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