Biphasic cortical macro- and microstructural changes in autosomal dominant Alzheimer's disease.

ABSTRACT:

Introduction

A biphasic model for brain structural changes in preclinical Alzheimer's disease (AD) could reconcile some conflicting and paradoxical findings in observational studies and anti-amyloid clinical trials.

Methods

In this study we tested this model fitting linear versus quadratic trajectories and computed the timing of the inflection points vertexwise of cortical thickness and cortical diffusivity-a novel marker of cortical microstructure-changes in 389 participants from the Dominantly Inherited Alzheimer Network.

Results

In early preclinical AD, between 20 and 15 years before estimated symptom onset, we found increases in cortical thickness and decreases in cortical diffusivity followed by cortical thinning and cortical diffusivity increases in later precli

SUBMITTER: Montal V 

PROVIDER: S-EPMC8043974 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature