Does the impact of intensive lifestyle intervention on cognitive function vary depending baseline level of frailty? An ancillary study to the Action for Health in Diabetes (Look AHEAD) Trial.

ABSTRACT:

Aims

To assess whether there is an opportune window when intensive lifestyle intervention (ILI) benefits cognitive function.

Methods

Standardized cognitive assessments were collected following ≥8 years of either ILI or a control condition of diabetes support and education (DSE) in 3708 individuals, ages 45-76 years at enrollment, with type 2 diabetes and overweight or obesity. Frailty index (FI) scores were used to group individuals at baseline into tertiles according to their age-related health status. Linear models were used to describe intervention adherence and cognitive function, with interaction terms to examine the consistency of relationships among tertiles.

Results

Worse baseline FI scores were associated with poorer subsequent performance in tests of attenti

SUBMITTER: Simpson FR 

PROVIDER: S-EPMC8046723 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature