Hypothalamic Rax⁺ tanycytes contribute to tissue repair and tumorigenesis upon oncogene activation in mice.

ABSTRACT: Hypothalamic tanycytes in median eminence (ME) are emerging as a crucial cell population that regulates endocrine output, energy balance and the diffusion of blood-born molecules. Tanycytes have recently been considered as potential somatic stem cells in the adult mammalian brain, but their regenerative and tumorigenic capacities are largely unknown. Here we found that Rax+ tanycytes in ME of mice are largely quiescent but quickly enter the cell cycle upon neural injury for self-renewal and regeneration. Mechanistically, Igf1r signaling in tanycytes is required for tissue repair under injury conditions. Furthermore, Braf oncogenic activation is sufficient to transform Rax+ tanycytes into actively dividing tumor cells that eventually develop into a papillary craniopharyngioma-like tumor. To

SUBMITTER: Mu W 

PROVIDER: S-EPMC8052410 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature