African Americans Have Differences in CSF Soluble TREM2 and Associated Genetic Variants.

ABSTRACT:

Objective

To evaluate for racial differences in triggering receptor expressed on myeloid cells 2 (TREM2), a key immune mediator in Alzheimer disease, the levels of CSF soluble TREM2 (sTREM2), and the frequency of associated genetic variants were compared in groups of individuals who self-reported their race as African American (AA) or non-Hispanic White (NHW).

Methods

Community-dwelling older research participants underwent measurement of CSF sTREM2 concentrations and genetic analyses.

Results

The primary cohort included 91 AAs and 868 NHWs. CSF sTREM2 levels were lower in the AA compared with the NHW group (1,336 ± 470 vs 1,856 ± 624 pg/mL, p < 0.0001). AAs were more likely to carry TREM2 coding variants (15% vs 3%, p < 0.0001), which were associ

SUBMITTER: Schindler SE 

PROVIDER: S-EPMC8054965 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature