Ontology highlight
ABSTRACT:
SUBMITTER: Ma X
PROVIDER: S-EPMC8054978 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20170904 41
We report the use of isolable primary and secondary alkylcarbastannatrane nucleophiles in site-specific fluorination reactions. These reactions occur without the need for transition metal catalysis or in situ activation of the nucleophile. In the absence of the carbastannatrane backbone, alkyltin nucleophiles exhibit no activity towards fluorination. When enantioenriched alkylcarbastannatranes are employed, fluorination occurs predominately via a stereoinvertive mechanism to generate highly enan ...[more]