Molecular Epidemiology of Hypervirulent Carbapenemase-Producing Klebsiella pneumoniae.

ABSTRACT:

Objective

To investigate the overall distributions of key virulence genes in Klebsiella pneumoniae, especially the hypervirulent bla_KPC-positive K. pneumoniae (Hv-bla_KPC(+)-KP).

Methods

A total of 521 complete genomes of K. pneumoniae from GenBank were collected and analyzed. Multilocus sequence typing, molecular serotyping, antibiotic-resistance, virulence genes and plasmid replicon typing were investigated.

Results

Positive rates of virulence genes highly varied, ranging from 2.9 (c-rmpA/A2) to 99.6% (entB). Totally 207 strains presented positive fimH, mrkD, entB and wzi and 190 showed positive fimH, mrkD, entB, irp2 and wzi, which we

SUBMITTER: Hu D 

PROVIDER: S-EPMC8058458 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature