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Molecular Epidemiology of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae in Serbia from 2013 to 2016.

ABSTRACT: Twenty-seven colistin-resistant, carbapenemase-producing Klebsiella pneumoniae isolates were identified from hospitals in Serbia. All isolates were blaCTX-M-15 positive; ST101, ST888, ST437, ST336, and ST307 were blaOXA-48 positive; and ST340 was blaNDM-1 positive. ST307 had an insertion, and ST336 had a premature stop codon in the mgrB gene. Amino acid substitutions were detected in PmrAB of isolates ST101, ST888, ST336, and ST307. The mcr-1 and mcr-2 were not detected. An increase in phoP, phoQ, and pmrK gene transcription was detected for all sequence types.

SUBMITTER: Novovic K 

PROVIDER: S-EPMC5404574 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Molecular Epidemiology of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae in Serbia from 2013 to 2016.

Novović Katarina K   Trudić Anika A   Brkić Snežana S   Vasiljević Zorica Z   Kojić Milan M   Medić Deana D   Ćirković Ivana I   Jovčić Branko B  

Antimicrobial agents and chemotherapy 20170424 5

Twenty-seven colistin-resistant, carbapenemase-producing <i>Klebsiella pneumoniae</i> isolates were identified from hospitals in Serbia. All isolates were <i>bla</i><sub>CTX-M-15</sub> positive; ST101, ST888, ST437, ST336, and ST307 were <i>bla</i><sub>OXA-48</sub> positive; and ST340 was <i>bla</i><sub>NDM-1</sub> positive. ST307 had an insertion, and ST336 had a premature stop codon in the <i>mgrB</i> gene. Amino acid substitutions were detected in PmrAB of isolates ST101, ST888, ST336, and ST  ...[more]

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