Dataset Information

Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients.

ABSTRACT:

Background

This study aimed to investigate the correlation of sirtuin 2 (SIRT2) with acute ischemic stroke (AIS) risk, severity, inflammation, and prognosis.

Methods

A hundred and sixty-four first episode AIS patients and 164 age and gender matched non-AIS patients with high-stroke-risk factors (controls) were enrolled. Peripheral blood was collected and serum was separated for SIRT2 and pro-inflammatory cytokines detection by enzyme-linked immunosorbent assay. AIS patients were continually followed up to 36 months or death, then recurrence-free survival (RFS) and overall survival (OS) were calculated.

Results

Serum SIRT2 expression was increased in AIS patients compared to controls (p < 0.001), then receiver operative characteristic curve disclosed that the serum SIRT2 expression could differentiate AIS patients from controls with a good area under curve of 0.890 (95%CI: 0.854-0.926), a sensitivity of 78.7% and a specificity of 91.5% at the best cut-off point. Serum SIRT2 expression was positively correlated with National Institute of Health stroke scale score (p < 0.001), serum tumor necrosis factor-α (p < 0.001), interleukin (IL)-6 (p = 0.012) and IL-17 (p < 0.001) expressions in AIS patients. In addition, serum SIRT2 expression was elevated in recurrent/dead AIS patients compared to non-recurrent/dead AIS patients (p = 0.025), and was also increased in dead AIS patients compared to survivors (p = 0.006). Moreover, RFS (p = 0.029) and OS (p = 0.049) were both worse in AIS patients with SIRT2 high expression compared to AIS patients with SIRT2 low expression.

Conclusion

SIRT2 may serve as a marker for AIS risk and prognosis in clinical practice.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC8059742 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Publications

Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients.

Zhang Yun Y Yan Qianfeng Q Zhang Yan Y

Journal of clinical laboratory analysis 20210222 4

<h4>Background</h4>This study aimed to investigate the correlation of sirtuin 2 (SIRT2) with acute ischemic stroke (AIS) risk, severity, inflammation, and prognosis.<h4>Methods</h4>A hundred and sixty-four first episode AIS patients and 164 age and gender matched non-AIS patients with high-stroke-risk factors (controls) were enrolled. Peripheral blood was collected and serum was separated for SIRT2 and pro-inflammatory cytokines detection by enzyme-linked immunosorbent assay. AIS patients were c ...[more]

PMID: 33616302

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Dataset Information

Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients.

Background

Methods

Results

Conclusion

Publications

Overexpression of sirtuin 2 and its association with prognosis in acute ischemic stroke patients.

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