Distinct cytokine profiles associated with COVID-19 severity and mortality.

ABSTRACT:

Background

Markedly elevated levels of proinflammatory cytokines and defective type-I interferon responses were reported in patients with coronavirus disease 2019 (COVID-19).

Objective

We sought to determine whether particular cytokine profiles are associated with COVID-19 severity and mortality.

Methods

Cytokine concentrations and severe acute respiratory syndrome coronavirus 2 antigen were measured at hospital admission in serum of symptomatic patients with COVID-19 (N = 115), classified at hospitalization into 3 respiratory severity groups: no need for mechanical ventilatory support (No-MVS), intermediate severity requiring mechanical ventilatory support (MVS), and critical severity requiring extracorporeal membrane oxygenation (ECMO). Principal-component analysis

SUBMITTER: Dorgham K 

PROVIDER: S-EPMC8061091 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature