Multiomics integrative analysis identifies <i>APOE</i> allele-specific blood biomarkers associated to Alzheimer's disease etiopathogenesis.

ABSTRACT: Alzheimer's disease (AD) is the most common form of dementia, currently affecting 35 million people worldwide. Apolipoprotein E (APOE) ε4 allele is the major risk factor for sporadic, late-onset AD (LOAD), which comprises over 95% of AD cases, increasing the risk of AD 4-12 fold. Despite this, the role of APOE in AD pathogenesis is still a mystery. Aiming for a better understanding of APOE-specific effects, the ADAPTED consortium analysed and integrated publicly available data of multiple OMICS technologies from both plasma and brain stratified by APOE haplotype (APOE2, APOE3 and APOE4). Combining genome-wide association studies (GWAS) with differential mRNA and protein expression analyses and single-nuclei transcriptomics, we identified genes and pathways contributing

SUBMITTER: Madrid L 

PROVIDER: S-EPMC8064208 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature