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COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study.

ABSTRACT:

SUBMITTER: Hall VJ 

PROVIDER: S-EPMC8064668 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study.

Hall Victoria Jane VJ   Foulkes Sarah S   Saei Ayoub A   Andrews Nick N   Oguti Blanche B   Charlett Andre A   Wellington Edgar E   Stowe Julia J   Gillson Natalie N   Atti Ana A   Islam Jasmin J   Karagiannis Ioannis I   Munro Katie K   Khawam Jameel J   Chand Meera A MA   Brown Colin S CS   Ramsay Mary M   Lopez-Bernal Jamie J   Hopkins Susan S  

Lancet (London, England) 20210423 10286

<h4>Background</h4>BNT162b2 mRNA and ChAdOx1 nCOV-19 adenoviral vector vaccines have been rapidly rolled out in the UK from December, 2020. We aimed to determine the factors associated with vaccine coverage for both vaccines and documented the vaccine effectiveness of the BNT162b2 mRNA vaccine in a cohort of health-care workers undergoing regular asymptomatic testing.<h4>Methods</h4>The SIREN study is a prospective cohort study among staff (aged ≥18 years) working in publicly-funded hospitals in  ...[more]

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