Dataset Information

Dual Effect of PER2 C111G Polymorphism on Cognitive Functions across Progression from Subjective Cognitive Decline to Mild Cognitive Impairment.

ABSTRACT:

Background

Periodic circadian protein homolog 2 (PER2) has a role in the intracellular signaling pathways of long-term potentiation and has implications for synaptic plasticity. We aimed to assess the association of PER2 C111G polymorphism with cognitive functions in subjective cognitive decline (SCD).

Methods

Forty-five SCD patients were included in this study. All participants underwent extensive neuropsychological investigation, analysis of apolipoprotein E (APOE) and PER2 genotypes, and neuropsychological follow-up every 12 or 24 months for a mean time of 9.87 ± 4.38 years.

Results

Nine out of 45 patients (20%) were heterozygous carriers of the PER2 C111G polymorphism (G carriers), while 36 patients (80%) were not carriers of the G allele (G non-carriers). At baseline, G carriers had a higher language composite score compared to G non-carriers. During follow-up, 15 (34.88%) patients progressed to mild cognitive impairment (MCI). In this group, we found a significant interaction between PER2 G allele and follow-up time, as carriers of G allele showed greater worsening of executive function, visual-spatial ability, and language composite scores compared to G non-carriers.

Conclusions

PER2 C111G polymorphism is associated with better language performance in SCD patients. Nevertheless, as patients progress to MCI, G allele carriers showed a greater worsening in cognitive performance compared to G non-carriers. The effect of PER2 C111G polymorphism depends on the global cognitive status of patients.

SUBMITTER: Mazzeo S

PROVIDER: S-EPMC8074126 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Publications

Dual Effect of <i>PER2</i> C111G Polymorphism on Cognitive Functions across Progression from Subjective Cognitive Decline to Mild Cognitive Impairment.

Mazzeo Salvatore S Bessi Valentina V Bagnoli Silvia S Giacomucci Giulia G Balestrini Juri J Padiglioni Sonia S Tomaiuolo Giulia G Ingannato Assunta A Ferrari Camilla C Bracco Laura L Sorbi Sandro S Nacmias Benedetta B

Diagnostics (Basel, Switzerland) 20210418 4

<h4>Background</h4>Periodic circadian protein homolog 2 (<i>PER2</i>) has a role in the intracellular signaling pathways of long-term potentiation and has implications for synaptic plasticity. We aimed to assess the association of PER2 C111G polymorphism with cognitive functions in subjective cognitive decline (SCD).<h4>Methods</h4>Forty-five SCD patients were included in this study. All participants underwent extensive neuropsychological investigation, analysis of apolipoprotein E (<i>APOE</i>) ...[more]

PMID: 33919572

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