Potential Mimicry of Viral and Pancreatic β Cell Antigens Through Non-Spliced and <i>cis</i>-Spliced <i>Zwitter</i> Epitope Candidates in Type 1 Diabetes.

ABSTRACT: Increasing evidence suggests that post-translational peptide splicing can play a role in the immune response under pathological conditions. This seems to be particularly relevant in Type 1 Diabetes (T1D) since post-translationally spliced epitopes derived from T1D-associated antigens have been identified among those peptides bound to Human Leucocyte Antigen (HLA) class I and II complexes. Their immunogenicity has been confirmed through CD4⁺ and CD8⁺ T cell-mediated responses in T1D patients. Spliced peptides theoretically have a large sequence variability. This might increase the frequency of viral-human zwitter peptides, i.e. peptides that share a complete sequence homology irrespective of whether they originate from human or viral antigens, thereby imp

SUBMITTER: Mishto M 

PROVIDER: S-EPMC8082463 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature