Dynamic Change and Clinical Relevance of Postinfectious SARS-CoV-2 Antibody Responses.

ABSTRACT:

Background

Although reports suggest that most individuals with coronavirus disease 2019 (COVID-19) develop detectable antibodies postinfection, the kinetics, durability, and relative differences between immunoglobulin M (IgM) and immunoglobulin G (IgG) responses beyond the first few weeks after symptom onset remain poorly understood.

Methods

Within a large, well-phenotyped, diverse, prospective cohort of subjects with and without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR)-confirmed infection and historical controls derived from cohorts with high prevalence of viral coinfections and samples taken during prior flu seasons, we measured SARS-CoV-2 serological responses (both IgG and IgM) using commercially available assays. We ca

SUBMITTER: Mallon PWG 

PROVIDER: S-EPMC8083770 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature