Family history and pelvic organ prolapse: a systematic review and meta-analysis.

ABSTRACT:

Introduction and hypothesis

Numerous analytic observational studies assess family history as a risk factor for POP and report a wide range of associations. This review aims to systematically evaluate the role of family history of POP in relation to POP risk and its recurrence.

Methods

A review was performed of the PubMed/MEDLINE database with search criteria specifying family history, risk factors, POP, and their synonyms as title/abstract keywords, as well as MESH terms, up to March 2020. We aggregated evidence across studies with fixed effects (FE) and random effects (RE) meta-analysis.

Results

Forty-three articles underwent full-text review. Eighteen independent studies evaluating the relationship between family history of POP and POP risk in 3639 POP cases and 10,

SUBMITTER: Samimi P 

PROVIDER: S-EPMC8086380 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature