FcγRIIb on CD11c⁺ cells modulates serum cholesterol and triglyceride levels and differentially affects atherosclerosis in male and female Ldlr^-/- mice.

ABSTRACT:

Background and aims

Circulating levels of oxidized lipoprotein (oxLDL) correlate with myocardial infarction risk and atherosclerosis severity. Our previous study demonstrates that oxLDL immune complexes (oxLDL-ICs) can signal through FcγRs on bone marrow-derived dendritic cells (BMDCs) and enhance their activation and inflammatory cytokine secretion. While global FcγR^-/- studies have shown that activating FcγRs are proatherogenic, the role of the inhibitory FcγRIIb is unclear. We sought to determine the role of DC-specific FcγRIIb in atherosclerosis.

Methods

Bone marrow chimeras were generated by rescuing lethally irradiated Ldlr^-/- mice with hematopoietic cells from littermate CD11c-Cre⁺ or CD11c-Cre^-Fcgr2b^fl/fl donors.

SUBMITTER: Marvin J 

PROVIDER: S-EPMC8086422 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature