The promises and limitations of N-acetylcysteine as a potentiator of first-line and second-line tuberculosis drugs.
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ABSTRACT:
SUBMITTER: Vilcheze C
PROVIDER: S-EPMC8092890 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
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The promises and limitations of <i>N-</i>acetylcysteine as a potentiator of first-line and second-line tuberculosis drugs.
Vilchèze Catherine C Jacobs William R WR
Antimicrobial agents and chemotherapy 20210222 5
<i>N-</i>acetylcysteine (NAC) is most commonly used for the treatment of acetaminophen overdose and acetaminophen-induced liver injury. In patients infected with <i>Mycobacterium tuberculosis</i>, the causative agent of tuberculosis (TB), NAC is given to treat hepatotoxicity induced by TB drugs. We had previously shown that cysteine, a derivative of NAC, potentiated the activity of isoniazid, a first-line TB drug, by preventing the emergence of INH resistance and persistence in <i>M. tuberculosi ...[more]
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