Urinary metals and adipokines in midlife women: The Study of Women's Health Across the nation (SWAN).

ABSTRACT:

Background

Information on the associations between metal exposures and adipokines in human populations is limited and results are inconsistent. We evaluated the associations between metals and adipokines.

Methods

Urinary concentrations of 15 metals (arsenic, barium, cadmium, cobalt, cesium, copper, mercury, manganese, molybdenum, nickel, lead, antimony, tin, thallium, and zinc) were measured in 1999-2000 among 1228 women of the Study of Women's Health Across the Nation Multi-Pollutant Study. Serum adipokines including high molecular weight (HMW)-adiponectin, leptin, and soluble leptin receptor (sOB-R) were measured at the follow-up visit (2002-2003). Linear regression models with adaptive elastic-net (AENET) were fit to identify metals associated with adipokines and to compu

SUBMITTER: Wang X 

PROVIDER: S-EPMC8093324 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature