Increase of Vδ2⁺ T Cells That Robustly Produce IL-17A in Advanced Abdominal Aortic Aneurysm Tissues.

ABSTRACT: Abdominal aortic aneurysm (AAA) is a chronic dilation of the aorta with a tendency to enlarge and eventually rupture, which constitutes a major cause of cardiovascular mortality. Although T-cell infiltrates have been observed in AAA, the cellular, phenotypic, and functional characteristics of these tissue-infiltrating T cells are not fully understood. Here, we investigated the proportional changes of T-cell subsets-including CD4⁺ T cells, CD8⁺ T cells, and γδ T cells-and their effector functions in AAAs. We found that Vδ2⁺ T cells were presented at a higher frequency in aortic aneurysmal tissue compared to normal aortic tissue and PBMCs from patients with AAA. In contrast, no differences were observed in the frequencies of CD4⁺, CD8⁺,

SUBMITTER: Seo IH 

PROVIDER: S-EPMC8099614 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature