A New Panel-Estimated GFR, Including β₂-Microglobulin and β-Trace Protein and Not Including Race, Developed in a Diverse Population.

ABSTRACT:

Rationale and objective

Glomerular filtration rate (GFR) estimation based on creatinine and cystatin C (eGFR_cr-cys) is more accurate than estimated GFR (eGFR) based on creatinine or cystatin C alone (eGFR_cr or eGFR_cys, respectively), but the inclusion of creatinine in eGFR_cr-cys requires specification of a person's race. β₂-Microglobulin (B2M) and β-trace protein (BTP) are alternative filtration markers that appear to be less influenced by race than creatinine is.

Study design

Study of diagnostic test accuracy.

Setting and participants

Development in a pooled population of 7 studies with 5,017 participants with and without chronic kidney disease. External validation in a pooled population of 7 other studies with 2

SUBMITTER: Inker LA 

PROVIDER: S-EPMC8102017 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature