DOCK8 Expression in Regulatory T Cells Maintains their Stability and Limits Contact Hypersensitivity.

ABSTRACT: Chronic dermatitis is a hallmark of Dedicator of cytokinesis 8 (DOCK8) deficiency. The migration of DOCK8-deficient T cells to the skin and their survival there have been reported to be defective. Surprisingly, we found that Dock8^-/- mice demonstrated an exaggerated contact hypersensitivity (CHS) response to oxazolone with increased ear swelling, T-cell infiltration, and expression of Ifng. To understand the mechanisms of persistent skin inflammation in DOCK8 deficiency, we examined mice with selective deficiency of DOCK8 in T cells or T regulatory cells (Tregs) and found that both have exaggerated CHS. Moreover, oral tolerance to oxazolone, mediated by Tregs, was impaired in Dock8^-/- mice. Transfer of Tregs from oxazolone-sensitized wild-type mice, but not Dock8

SUBMITTER: Wilkie H 

PROVIDER: S-EPMC8102650 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature