Genome-Wide Association Study Meta-Analysis for Parkinson Disease Motor Subtypes.

ABSTRACT:

Objective

To discover genetic determinants of Parkinson disease (PD) motor subtypes, including tremor dominant (TD) and postural instability/gait difficulty (PIGD) forms.

Methods

In 3,212 PD cases of European ancestry, we performed a genome-wide association study (GWAS) examining 2 complementary outcome traits derived from the Unified Parkinson's Disease Rating Scale, including dichotomous motor subtype (TD vs PIGD) or a continuous tremor/PIGD score ratio. Logistic or linear regression models were adjusted for sex, age at onset, disease duration, and 5 ancestry principal components, followed by meta-analysis.

Results

Among 71 established PD risk variants, we detected multiple suggestive associations with PD motor subtype, including GPNMB (rs199351, p<

SUBMITTER: Alfradique-Dunham I 

PROVIDER: S-EPMC8112852 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature