Sequential implementation of DSC-MR perfusion and dynamic [¹⁸F]FET PET allows efficient differentiation of glioma progression from treatment-related changes.

ABSTRACT:

Purpose

Perfusion-weighted MRI (PWI) and O-(2-[¹⁸F]fluoroethyl-)-l-tyrosine ([¹⁸F]FET) PET are both applied to discriminate tumor progression (TP) from treatment-related changes (TRC) in patients with suspected recurrent glioma. While the combination of both methods has been reported to improve the diagnostic accuracy, the performance of a sequential implementation has not been further investigated. Therefore, we retrospectively analyzed the diagnostic value of consecutive PWI and [¹⁸F]FET PET.

Methods

We evaluated 104 patients with WHO grade II-IV glioma and suspected TP on conventional MRI using PWI and dynamic [¹⁸F]FET PET. Leakage corrected maximum relative cerebral blood volumes (rCBV_max) were obtained from dynamic

SUBMITTER: Steidl E 

PROVIDER: S-EPMC8113145 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature