Remote and Persistent Alterations in Glutamate Receptor Subunit Composition Induced by Spreading Depolarizations in Rat Brain.
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ABSTRACT:
SUBMITTER: Barhorst KA
PROVIDER: S-EPMC8113318 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
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Remote and Persistent Alterations in Glutamate Receptor Subunit Composition Induced by Spreading Depolarizations in Rat Brain.
Barhorst Kinsey A KA Alfawares Yara Y McGuire Jennifer L JL Danzer Steve C SC Hartings Jed A JA Ngwenya Laura B LB
Cellular and molecular neurobiology 20201112 4
Spreading depolarizations (SDs) are massive breakdowns of ion homeostasis in the brain's gray matter and are a necessary pathologic mechanism for lesion development in various injury models. However, injury-induced SDs also propagate into remote, healthy tissue where they do not cause cell death, yet their functional long-term effects are unknown. Here we induced SDs in uninjured cortex and hippocampus of Sprague-Dawley rats to study their impact on glutamate receptor subunit expression after th ...[more]
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