Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans.

ABSTRACT: Dietary restriction (DR) increases lifespan in a broad variety of organisms and improves health in humans. However, long-term transgenerational consequences of dietary interventions are poorly understood. Here, we investigated the effect of DR by temporary fasting (TF) on mortality risk, age-specific reproduction and fitness across three generations of descendants in Caenorhabditis elegans. We show that while TF robustly reduces mortality risk and improves late-life reproduction of the individuals subject to TF (P₀), it has a wide range of both positive and negative effects on their descendants (F₁-F₃). Remarkably, great-grandparental exposure to TF in early life reduces fitness and increases mortality risk of F₃ descendants to such an ext

SUBMITTER: Ivimey-Cook ER 

PROVIDER: S-EPMC8113902 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature