Nonsurgical Prevention Strategies in BRCA1 and BRCA2 Mutation Carriers.

ABSTRACT:

Background

Female carriers of a BRCA1 or 2 germline mutation face a high lifetime risk to develop breast and ovarian cancer. Risk-reducing surgery, such as prophylactic bilateral mastectomy and prophylactic bilateral salpingo-oophorectomy, are proven strategies to prevent breast and ovarian cancer. These procedures are, however, associated with considerable side effects, and the uptake of these highly effective interventions is therefore low in many countries. This highlights the need for alternative and noninvasive strategies for risk reduction in mutation carriers.

Summary

While endocrine treatments with tamoxifen and aromatase inhibitors (AI) have been shown to be effective in secondary prevention, their benefit in primary prevention has never been prospecti

SUBMITTER: Singer CF 

PROVIDER: S-EPMC8114042 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature