Integrated-omics endotyping of infants with rhinovirus bronchiolitis and risk of childhood asthma.

ABSTRACT:

Background

Young children with rhinovirus (RV) infection-particularly bronchiolitis-are at high risk for developing childhood asthma. Emerging evidence suggests clinical heterogeneity within RV bronchiolitis. However, little is known about these biologically distinct subgroups (endotypes) and their relations with asthma risk.

Objective

We aimed to identify RV bronchiolitis endotypes and examine their longitudinal relations with asthma risk.

Methods

As part of a multicenter prospective cohort study of infants (age <12 months) hospitalized for bronchiolitis, we integrated clinical, RV species (RV-A, RV-B, and RV-C), nasopharyngeal microbiome (16S rRNA gene sequencing), cytokine, and metabolome (liquid chromatography tandem mass spectrometry) data collected at hospitaliz

SUBMITTER: Raita Y 

PROVIDER: S-EPMC8116357 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature