Microglial Gi-dependent dynamics regulate brain network hyperexcitability.
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ABSTRACT:
SUBMITTER: Merlini M
PROVIDER: S-EPMC8118167 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Microglial G<sub>i</sub>-dependent dynamics regulate brain network hyperexcitability.
Merlini Mario M Rafalski Victoria A VA Ma Keran K Kim Keun-Young KY Bushong Eric A EA Rios Coronado Pamela E PE Yan Zhaoqi Z Mendiola Andrew S AS Sozmen Elif G EG Ryu Jae Kyu JK Haberl Matthias G MG Madany Matthew M Sampson Daniel Naranjo DN Petersen Mark A MA Bardehle Sophia S Tognatta Reshmi R Dean Terry T Acevedo Rosa Meza RM Cabriga Belinda B Thomas Reuben R Coughlin Shaun R SR Ellisman Mark H MH Palop Jorge J JJ Akassoglou Katerina K
Nature neuroscience 20201214 1
Microglial surveillance is a key feature of brain physiology and disease. Here, we found that G<sub>i</sub>-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating Mg<sup>PTX</sup> mice to genetically inhibit G<sub>i</sub> in microglia, we show that sustained reduction of microglia brain surveillance and directed process motility induced spontaneous seizures and increased hypersynchrony after physiologically evoked neuronal activity in awake adult mice. Thus, G<su ...[more]
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