Recognition memory and divergent cognitive profiles in prodromal genetic frontotemporal dementia.

ABSTRACT: Although executive dysfunction is the characteristic cognitive marker of behavioral variant frontotemporal dementia (bvFTD), episodic memory deficits are relatively common, and may be present even during the prodromal disease phase. In a cohort of mutation carriers with mild behavioral and/or cognitive symptoms consistent with prodromal bvFTD, we aimed to investigate patterns of performance on an abbreviated list learning task, with a particular focus on recognition memory. We further aimed to characterize the cognitive prodromes associated with the three major genetic causes of frontotemporal dementia, as emerging evidence suggests there may be subtle differences in cognitive profiles among carriers of different genetic mutations. Participants included 57 carriers of a pathogenic mutation

SUBMITTER: Barker MS 

PROVIDER: S-EPMC8119343 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature