Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer.
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ABSTRACT:
SUBMITTER: Shinde-Jadhav S
PROVIDER: S-EPMC8119713 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Role of neutrophil extracellular traps in radiation resistance of invasive bladder cancer.
Shinde-Jadhav Surashri S Mansure Jose Joao JJ Rayes Roni F RF Marcq Gautier G Ayoub Mina M Skowronski Rodrigo R Kool Ronald R Bourdeau France F Brimo Fadi F Spicer Jonathan J Kassouf Wassim W
Nature communications 20210513 1
Radiation therapy (RT) is used in the management of several cancers; however, tumor radioresistance remains a challenge. Polymorphonuclear neutrophils (PMNs) are recruited to the tumor immune microenvironment (TIME) post-RT and can facilitate tumor progression by forming neutrophil extracellular traps (NETs). Here, we demonstrate a role for NETs as players in tumor radioresistance. Using a syngeneic bladder cancer model, increased NET deposition is observed in the TIME of mice treated with RT an ...[more]
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