Ontology highlight
ABSTRACT:
SUBMITTER: Ueda HR
PROVIDER: S-EPMC8121164 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Ueda Hiroki R HR Ertürk Ali A Chung Kwanghun K Gradinaru Viviana V Chédotal Alain A Tomancak Pavel P Keller Philipp J PJ
Nature reviews. Neuroscience 20200201 2
State-of-the-art tissue-clearing methods provide subcellular-level optical access to intact tissues from individual organs and even to some entire mammals. When combined with light-sheet microscopy and automated approaches to image analysis, existing tissue-clearing methods can speed up and may reduce the cost of conventional histology by several orders of magnitude. In addition, tissue-clearing chemistry allows whole-organ antibody labelling, which can be applied even to thick human tissues. By ...[more]