Phenome-wide and expression quantitative trait locus associations of coronavirus disease 2019 genetic risk loci.

ABSTRACT: While several genes and clinical traits have been associated with higher risk of severe coronavirus disease 2019 (COVID-19), how host genetic variants may interact with these parameters and contribute to severe disease is still unclear. Herein, we performed phenome-wide association study, tissue and immune-cell-specific expression quantitative trait locus (eQTL)/splicing quantitative trait locus, and colocalization analyses for genetic risk loci suggestively associated with severe COVID-19 with respiratory failure. Thirteen phenotypes/traits were associated with the severe COVID-19-associated loci at the genome-wide significance threshold, including monocyte counts, fat metabolism traits, and fibrotic idiopathic interstitial pneumonia. In addition, we identified tissue and immune subtype-s

SUBMITTER: Moon CY 

PROVIDER: S-EPMC8129787 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature