Association of obesity-related inflammatory pathways with lung function and exercise capacity.

ABSTRACT:

Background

Obesity has multifactorial effects on lung function and exercise capacity. The contributions of obesity-related inflammatory pathways to alterations in lung function remain unclear.

Research question

To examine the association of obesity-related inflammatory pathways with pulmonary function, exercise capacity, and pulmonary-specific contributors to exercise intolerance.

Method

We examined 695 patients who underwent cardiopulmonary exercise testing (CPET) with invasive hemodynamic monitoring at Massachusetts General Hospital between December 2006-June 2017. We investigated the association of adiponectin, leptin, resistin, IL-6, CRP, and insulin resistance (HOMA-IR) with pulmonary function and exercise parameters using multivariable linear regression.

Resu

SUBMITTER: McNeill JN 

PROVIDER: S-EPMC8144063 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature