Aspirin reduces the incidence of metastasis in a pre-clinical study of Braf mutant serrated colorectal neoplasia.

ABSTRACT:

Background

Aspirin reduces the incidence of conventional adenomas driven by APC mutation and thus colorectal cancer. The effect of aspirin on the ~20% of colorectal cancers arising via BRAF mutation is yet to be established.

Methods

Braf^V637E/+;Villin-Cre^ERT2/+ mice were allocated to a control (n = 86) or aspirin-supplemented (n = 83) diet. After 14 months the incidence of murine serrated lesions, carcinoma and distant metastases were measured by histological examination. RNA was extracted from carcinomas from each cohort and subjected to sequencing to identify differentially expressed genes and molecular pathways.

Results

Aspirin did not reduce the incidence of murine serrated lesions or carcinoma when compared to control, however, did significa

SUBMITTER: Kane AM 

PROVIDER: S-EPMC8144376 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature