Label-free characterization of organic nanocarriers reveals persistent single molecule cores for hydrocarbon sequestration.

ABSTRACT: Self-assembled molecular nanostructures embody an enormous potential for new technologies, therapeutics, and understanding of molecular biofunctions. Their structure and function are dependent on local environments, necessitating in-situ/operando investigations for the biggest leaps in discovery and design. However, the most advanced of such investigations involve laborious labeling methods that can disrupt behavior or are not fast enough to capture stimuli-responsive phenomena. We utilize X-rays resonant with molecular bonds to demonstrate an in-situ nanoprobe that eliminates the need for labels and enables data collection times within seconds. Our analytical spectral model quantifies the structure, molecular composition, and dynamics of a copolymer micelle drug delivery platform using re

SUBMITTER: McAfee T 

PROVIDER: S-EPMC8149835 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature