In vivo monitoring of tissue regeneration using a ratiometric lysosomal AIE probe.

ABSTRACT: Tissue regeneration is a crucial self-renewal capability involving many complex biological processes. Although transgenic techniques and fluorescence immunohistochemical staining have promoted our understanding of tissue regeneration, simultaneous quantification and visualization of tissue regeneration processes is not easy to achieve. Herein, we developed a simple and quantitative method for the real-time and non-invasive observation of the process of tissue regeneration. The synthesized ratiometric aggregation-induced-emission (AIE) probe exhibits high selectivity and reversibility for pH responses, good ability to map lysosomal pH both in vitro and in vivo, good biocompatibility and excellent photostability. The caudal fin regeneration of a fish model (medaka larvae) was m

SUBMITTER: Shi X 

PROVIDER: S-EPMC8157324 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature