The role of l-histidine as molecular tongs: a strategy of grasping Tb³⁺ using ZIF-8 to design sensors for monitoring an anthrax biomarker on-the-spot.

ABSTRACT: In this study, a novel lanthanide-doped nanoprobe for monitoring dipicolinic acid (DPA), a unique biomarker of Bacillus anthracis, was constructed by coordination of Tb³⁺ with l-histidine (His) functionalized ZIF-8 (His@ZIF-8). After being functionalized with His, the resultant His@ZIF-8 had abundant carboxyl and amino groups, which like tongs help His@ZIF-8 "grasp" Tb³⁺ firmly to form a stable lanthanide-doped nanoparticle (His@ZIF-8/Tb³⁺). Owing to the unsaturated coordination of Tb³⁺ with the amino acid group, the resultant His@ZIF-8/Tb³⁺ showed reserved response sites of Tb³⁺ to DPA because of its unique molecular structure. After the His@ZIF-8/Tb³⁺ coordination with DPA, the intrinsic fluorescence emis

SUBMITTER: Guo L 

PROVIDER: S-EPMC8157567 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature